Research lines

1. Nanomaterials development for tissue regeneration in Dentistry

This research line focuses on the development of novel bioactive nano-biomaterials loaded with ions and molecules to facilitate tissue regeneration. These studies investigate their compatibility, bioactivity, antibacterial properties, the produced effect on essential substrate characteristics and their tissue regeneration ability. Current investigations attempt to generate dentin and bone remineralization.

• https://doi.org/10.1111/iej.12918
• https://doi.org/10.1007/s00784-017-2072-8
• https://doi.org/10.1016/j.jmbbm.2017.01.026
• https://doi.org/10.1371/journal.pone.0166217
• https://doi.org/10.3390/ma11061013

2. Interactions of restorative biomaterials with the tooth substrate

The main purpose of this research line is the study of the resin-dentin inter-diffusion zone, delving into the physic, chemical, mechanical and biological properties at the bonded interfaces. Nowadays, the front-line topic concerns the degradation and remineralization of non-calcified dentin collagen at the dentin-polymer interface.

• https://doi.org/10.4317/medoral.22751
• https://doi.org/10.1016/j.jdent.2018.10.003
• https://doi.org/10.1016/j.jdent.2018.04.006
• https://doi.org/10.1016/j.jmbbm.2017.04.030
• https://doi.org/10.1007/s00784-016-1738-y
• https://doi.org/10.1016/j.jmbbm.2015.09.003
• https://doi.org/10.1016/j.dental.2015.03.013

3. Nanoscale analysis of pathological human trabecular bone

This research line aims to standardize study protocols on human trabecular bone, in order to assess the biochemical components and nanomechanical behavior of trabecular bone affected or not by bone diseases, and to evaluate and develop successful therapies to increase bone quality.

• https://doi.org/10.1016/j.injury.2018.07.035
• https://doi.org/10.1016/j.injury.2018.07.034
• https://doi.org/10.1016/S0020-1383(17)30791-X
• https://doi.org/10.1016/S0020-1383(17)30790-8

4. Dentin hypersensitivity

Tooth tissue wear due to abrasion, attrition, abfraction and erosion has become a concern, as the population ages. Exposed dentin is subject to physical and chemical challenges and frequently leads to caries and hypersensitivity. Dentin hypersensitivity primarily results from the exposure and patency of dentinal tubules. The aim of the present research line is to attain the reduction in dentin permeability by the occlusion of tubules, through remineralization and mechanical recovery of eroded and demineralized dentin. Understanding that restoring of dentin does not only relate to tubule occlusion but also to an improvement on mechanical properties and mineralization at the intertubular dentin, that will impair the progression of eroded lesions.

• https://doi.org/10.1007/s00784-018-2548-1
• https://doi.org/10.1111/iej.12807
• https://doi.org/10.1016/j.actbio.2018.03.033
• https://doi.org/10.1007/s00784-018-2372-7