Publications

* 1. Toledano-Osorio, M., Muñoz-Soto, E., Toledano, M., Vallecillo-Rivas, M., Vallecillo, C., Ramos-García, P., & Osorio, R. (2022). Treating Gingival Recessions Using Coronally Advanced Flap or Tunnel Techniques with Autografts or Polymeric Substitutes: A Systematic Review and Meta-Analysis. Polymers, 14(7), 1453. https://doi.org/10.3390/polym14071453

*2. Cascales, Á. F., Moscardó, A. P., Toledano, M., Banerjee, A., & Sauro, S. (2022). An in-vitro investigation of the bond strength of experimental ion-releasing dental adhesives to caries-affected dentine after 1 year of water storage. Journal of dentistry, 119, 104075. https://doi.org/10.1016/j.jdent.2022.104075

*3. Toledano, M., Toledano-Osorio, M., Hannig, M., Carrasco-Carmona, Á., Osorio, M. T., García-Godoy, F., Cabello, I., & Osorio, R. (2022). Zn-containing Adhesives Facilitate Collagen Protection and Remineralization at the Resin-Dentin Interface: A Narrative Review. Polymers, 14(3), 642. https://doi.org/10.3390/polym14030642

*4. Bueno, J., Virto, L., Toledano-Osorio, M., Figuero, E., Toledano, M., Medina-Castillo, A. L., Osorio, R., Sanz, M., & Herrera, D. (2022). Antibacterial Effect of Functionalized Polymeric Nanoparticles on Titanium Surfaces Using an In Vitro Subgingival Biofilm Model. Polymers, 14(3), 358. https://doi.org/10.3390/polym14030358

*5. Toledano-Osorio, M., Osorio, R., Osorio, E., Medina-Castillo, A. L., & Toledano, M. (2021). Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study. Nanomaterials (Basel, Switzerland), 11(11), 3150. https://doi.org/10.3390/nano11113150

*6. Toledano-Osorio, M., Aguilera, F. S., Muñoz-Soto, E., Osorio, E., Toledano, M., Escames, G., Medina-Castillo, A. L., Osorio, M. T., López-López, M. T., Vallecillo-Rivas, M., & Osorio, R. (2021). Melatonin-doped polymeric nanoparticles induce high crystalline apatite formation in root dentin. Dental materials : official publication of the Academy of Dental Materials, 37(11), 1698–1713. https://doi.org/10.1016/j.dental.2021.09.001

*7. Vallecillo-Rivas, M., Toledano-Osorio, M., Vallecillo, C., Toledano, M., & Osorio, R. (2021). The Collagen Origin Influences the Degradation Kinetics of Guided Bone Regeneration Membranes. Polymers, 13(17), 3007. https://doi.org/10.3390/polym13173007

*8. Toledano, M., Osorio, M. T., Vallecillo-Rivas, M., Toledano-Osorio, M., Rodríguez-Archilla, A., Toledano, R., & Osorio, R. (2021). Efficacy of local antibiotic therapy in the treatment of peri-implantitis: A systematic review and meta-analysis. Journal of dentistry, 113, 103790. https://doi.org/10.1016/j.jdent.2021.103790

*9. Vallecillo, C., Toledano-Osorio, M., Vallecillo-Rivas, M., Toledano, M., & Osorio, R. (2021). In Vitro Biodegradation Pattern of Collagen Matrices for Soft Tissue Augmentation. Polymers, 13(16), 2633. https://doi.org/10.3390/polym13162633

*10. Vallecillo, C., Toledano-Osorio, M., Vallecillo-Rivas, M., Toledano, M., Rodriguez-Archilla, A., & Osorio, R. (2021). Collagen Matrix vs. Autogenous Connective Tissue Graft for Soft Tissue Augmentation: A Systematic Review and Meta-Analysis. Polymers, 13(11), 1810. https://doi.org/10.3390/polym13111810

*11. Toledano, M., Vallecillo-Rivas, M., Osorio, M. T., Muñoz-Soto, E., Toledano-Osorio, M., Vallecillo, C., Toledano, R., Lynch, C. D., Serrera-Figallo, M. A., & Osorio, R. (2021). Zn-Containing Membranes for Guided Bone Regeneration in Dentistry. Polymers, 13(11), 1797. https://doi.org/10.3390/polym13111797

*12. Toledano-Osorio, M., Toledano, M., Manzano-Moreno, F. J., Vallecillo, C., Vallecillo-Rivas, M., Rodriguez-Archilla, A., & Osorio, R. (2021). Alveolar Bone Ridge Augmentation Using Polymeric Membranes: A Systematic Review and Meta-Analysis. Polymers, 13(7), 1172. https://doi.org/10.3390/polym13071172

*13. Toledano-Osorio, M., Manzano-Moreno, F. J., Toledano, M., Osorio, R., Medina-Castillo, A. L., Costela-Ruiz, V. J., & Ruiz, C. (2021). Doxycycline-doped membranes induced osteogenic gene expression on osteoblastic cells. Journal of dentistry, 109, 103676. https://doi.org/10.1016/j.jdent.2021.103676

*14. Toledano, M., Aguilera, F. S., Osorio, E., Toledano-Osorio, M., Escames, G., Medina-Castillo, A. L., Toledano, R., Lynch, C. D., & Osorio, R. (2021). Melatonin-doped polymeric nanoparticles reinforce and remineralize radicular dentin: Morpho-histological, chemical and biomechanical studies. Dental materials : official publication of the Academy of Dental Materials, 37(7), 1107–1120. https://doi.org/10.1016/j.dental.2021.03.007

*15. Toledano-Osorio, M., Manzano-Moreno, F. J., Toledano, M., Medina-Castillo, A. L., Costela-Ruiz, V. J., Ruiz, C., & Osorio, R. (2021). Doxycycline-Doped Polymeric Membranes Induced Growth, Differentiation and Expression of Antigenic Phenotype Markers of Osteoblasts. Polymers, 13(7), 1063. https://doi.org/10.3390/polym13071063

*16. Toledano, M., Vallecillo-Rivas, M., Aguilera, F. S., Osorio, M. T., Osorio, E., & Osorio, R. (2021). Polymeric zinc-doped nanoparticles for high performance in restorative dentistry. Journal of dentistry, 107, 103616. https://doi.org/10.1016/j.jdent.2021.103616

*17. Toledano-Osorio, M., Manzano-Moreno, F. J., Ruiz, C., Toledano, M., & Osorio, R. (2021). Testing active membranes for bone regeneration: A review. Journal of dentistry, 105, 103580. https://doi.org/10.1016/j.jdent.2021.103580

*18. Toledano, M., Osorio, R., Vallecillo-Rivas, M., Osorio, E., Lynch, C. D., Aguilera, F. S., Toledano, R., & Sauro, S. (2021). Zn-doping of silicate and hydroxyapatite-based cements: Dentin mechanobiology and bioactivity. Journal of the mechanical behavior of biomedical materials, 114, 104232. https://doi.org/10.1016/j.jmbbm.2020.104232

*19. Arias-Moliz, M. T., Baca, P., Solana, C., Toledano, M., Medina-Castillo, A. L., Toledano-Osorio, M., & Osorio, R. (2021). Doxycycline-functionalized polymeric nanoparticles inhibit Enterococcus faecalis biofilm formation on dentine. International endodontic journal, 54(3), 413–426. https://doi.org/10.1111/iej.13436

*20. Bueno, J., Sánchez, M. C., Toledano-Osorio, M., Figuero, E., Toledano, M., Medina-Castillo, A. L., Osorio, R., Herrera, D., & Sanz, M. (2020). Antimicrobial effect of nanostructured membranes for guided tissue regeneration: an in vitro study. Dental materials : official publication of the Academy of Dental Materials, 36(12), 1566–1577. https://doi.org/10.1016/j.dental.2020.09.011

*21. Toledano, M., Carrasco-Carmona, Á., Medina-Castillo, A. L., Toledano-Osorio, M., & Osorio, R. (2020). Protein adsorption and bioactivity of functionalized electrospun membranes for bone regeneration. Journal of dentistry, 102, 103473. https://doi.org/10.1016/j.jdent.2020.103473

*22. Toledano, M., Toledano-Osorio, M., Carrasco-Carmona, Á., Vallecillo, C., Lynch, C. D., Osorio, M. T., & Osorio, R. (2020). State of the Art on Biomaterials for Soft Tissue Augmentation in the Oral Cavity. Part I: Natural Polymers-Based Biomaterials. Polymers, 12(8), 1850. https://doi.org/10.3390/polym12081850

*23. Toledano, M., Toledano-Osorio, M., Carrasco-Carmona, Á., Vallecillo, C., Toledano, R., Medina-Castillo, A. L., & Osorio, R. (2020). State of the Art on Biomaterials for Soft Tissue Augmentation in the Oral Cavity. Part II: Synthetic Polymers-Based Biomaterials. Polymers, 12(8), 1845. https://doi.org/10.3390/polym12081845

*24. Toledano, M., Asady, S., Toledano-Osorio, M., García-Godoy, F., Serrera-Figallo, M. A., Benítez-García, J. A., & Osorio, R. (2020). Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration. Polymers, 12(6), 1290. https://doi.org/10.3390/polym12061290

*25. Toledano, M., Toledano-Osorio, M., Osorio, R., Carrasco-Carmona, Á., Gutiérrez-Pérez, J. L., Gutiérrez-Corrales, A., Serrera-Figallo, M. A., Lynch, C. D., & Torres-Lagares, D. (2020). Doxycycline and Zinc Loaded Silica-Nanofibrous Polymers as Biomaterials for Bone Regeneration. Polymers, 12(5), 1201. https://doi.org/10.3390/polym12051201

*26. Toledano-Osorio, M., Osorio, R., Aguilera, F. S., Medina-Castillo, A. L., Toledano, M., Osorio, E., Acosta, S., Chen, R., & Aparicio, C. (2020). Polymeric nanoparticles protect the resin-dentin bonded interface from cariogenic biofilm degradation. Acta biomaterialia, 111, 316–326. https://doi.org/10.1016/j.actbio.2020.05.002

*27. Osorio, R., Carrasco-Carmona, Á., Toledano, M., Osorio, E., Medina-Castillo, A. L., Iskandar, L., Marques, A., Deb, S., & Toledano-Osorio, M. (2020). Ex vivo investigations on bioinspired electrospun membranes as potential biomaterials for bone regeneration. Journal of dentistry, 98, 103359. https://doi.org/10.1016/j.jdent.2020.103359

*28. Toledano, M., Osorio, E., Aguilera, F. S., Muñoz-Soto, E., Toledano-Osorio, M., López-López, M. T., Medina-Castillo, A. L., Carrasco-Carmona, Á., & Osorio, R. (2020). Polymeric nanoparticles for endodontic therapy. Journal of the mechanical behavior of biomedical materials, 103, 103606. https://doi.org/10.1016/j.jmbbm.2019.103606

*29. Toledano-Osorio, M., Aguilera, F. S., Osorio, R., Muñoz-Soto, E., Pérez-Álvarez, M. C., López-López, M. T., Lynch, C. D., & Toledano, M. (2020). Hydroxyapatite-based cements induce different apatite formation in radicular dentin. Dental materials : official publication of the Academy of Dental Materials, 36(1), 167–178. https://doi.org/10.1016/j.dental.2019.11.023

*30. Toledano, M., Toledano-Osorio, M., Navarro-Hortal, M. D., Varela-López, A., Osorio, R., & Quiles, J. L. (2019). Novel Polymeric Nanocarriers Reduced Zinc and Doxycycline Toxicity in the Nematode Caenorhabditis elegans. Antioxidants (Basel, Switzerland), 8(11), 550. https://doi.org/10.3390/antiox8110550

*31. Toledano, M., Gutierrez-Pérez, J. L., Gutierrez-Corrales, A., Serrera-Figallo, M. A., Toledano-Osorio, M., Rosales-Leal, J. I., Aguilar, M., Osorio, R., & Torres-Lagares, D. (2020). Novel non-resorbable polymeric-nanostructured scaffolds for guided bone regeneration. Clinical oral investigations, 24(6), 2037–2049. https://doi.org/10.1007/s00784-019-03068-8

*32. Toledano, M., Muñoz-Soto, E., Aguilera, F. S., Osorio, E., González-Rodríguez, M. P., Pérez-Álvarez, M. C., Toledano-Osorio, M., & Osorio, R. (2019). A zinc oxide-modified hydroxyapatite-based cement favored sealing ability in endodontically treated teeth. Journal of dentistry, 88, 103162. https://doi.org/10.1016/j.jdent.2019.06.009

*33. Toledano, M., Muñoz-Soto, E., Aguilera, F. S., Osorio, E., Pérez-Álvarez, M. C., García-Menocal, J. A., Toledano-Osorio, M., & Osorio, R. (2020). The mineralizing effect of zinc oxide-modified hydroxyapatite-based sealer on radicular dentin. Clinical oral investigations, 24(1), 285–299. https://doi.org/10.1007/s00784-019-02938-5

*34. Toledano, M., Aguilera, F. S., Cabello, I., Toledano-Osorio, M., Osorio, E., López-López, M. T., García-Godoy, F., Lynch, C. D., & Osorio, R. (2019). Silver-loaded nanoparticles affect ex-vivo mechanical behavior and mineralization of dentin. Medicina oral, patologia oral y cirugia bucal, 24(2), e156–e164. https://doi.org/10.4317/medoral.22885

*35. Toledano, M., Osorio, E., Aguilera, F. S., Toledano-Osorio, M., López-López, M. T., & Osorio, R. (2019). Stored potential energy increases and elastic properties alterations are produced after restoring dentin with Zn-containing amalgams. Journal of the mechanical behavior of biomedical materials, 91, 109–121. https://doi.org/10.1016/j.jmbbm.2018.12.002

*36. Sánchez MC, Toledano-Osorio M, Bueno J, Figuero E, Toledano M, Medina-Castillo AL, Osorio R, Herrera D, Sanz M. Antibacterial effects of polymeric PolymP-n Active nanoparticles. An in vitro biofilm study. Dent Mater. 2019 Jan;35(1):156-168. https://doi.org/10.1016/j.dental.2018.11.015

*37. Toledano M., Osorio R., Pérez-Álvarez M.C., Osorio E., Lynch C., Toledano-Osorio M. A zinc-doped endodontic cement facilitates functional mineralization and stress dissipation at the dentin Surface (2018) Medicina Oral, Patologia Oral y Cirugia Bucal, 23 (6), pp. e646-e655. https://doi.org/10.4317/medoral.22751

*38. Osorio R., Osorio E., Aguilera F.S., Medina-Castillo A.L., Toledano M., Toledano-Osorio M. Silver improves collagen structure and stability at demineralized dentin: A dynamic-mechanical and Raman analysis (2018) Journal of Dentistry pii: S0300-5712(18) 30537-2. https://doi.org/10.1016/j.jdent.2018.10.003

*39. Toledano M., Toledano-Osorio M., Guerado E., Caso E., Osorio E., Osorio R. Assessing bone quality through mechanical properties in postmenopausal trabecular bone (2018) Injury 49 (Suppl 2), pp. S3-S10. https://doi.org/10.1016/j.injury.2018.07.035

*40. Toledano M., Toledano-Osorio M., Guerado E., Caso E., Aguilera F.S., Osorio R. Biochemical assessment of nanostructures in human trabecular bone: Proposal of a Raman microspectroscopy based measurements protocol (2018) Injury 49 (Suppl 2), pp. S11-S21. https://doi.org/10.1016/j.injury.2018.07.034

*41. Toledano M, Cabello I, Osorio E, Aguilera FS, Medina-Castillo AL, Toledano-Osorio M, Osorio R. Zn-containing polymer nanogels promote cervical dentin remineralization. Clin Oral Investig. 2019 Mar;23(3):1197-1208. https://doi.org/10.1007/s00784-018-2548-1

*42. Toledano-Osorio M., Babu J.P., Osorio R., Medina-Castillo A.L., García-Godoy F., Toledano M. Modified polymeric nanoparticles exert in vitro antimicrobial activity against oral bacteria (2018) Materials (Basel) 11 (6). pii: E1013. https://doi.org/10.3390/ma11061013

*43. Toledano M., Osorio R., Osorio E., Cabello I., Toledano-Osorio M., Aguilera F.S. In vitro mechanical stimulation facilitates stress dissipation and sealing ability at the conventional glass ionomer cement-dentin interface (2018) Journal of Dentistry 73, pp. 61-69. https://doi.org/10.1016/j.jdent.2018.04.006

*44. Toledano-Osorio M., Osorio E., Aguilera F.S., Luis Medina-Castillo A.L., Toledano M., Osorio R. Improved reactive nanoparticles to treat dentin hypersensitivity (2018) Acta Biomaterialia 72, pp. 371-380. https://doi.org/10.1016/j.actbio.2018.03.033

*45. Toledano M., Toledano-Osorio M., Medina-Castillo A.L., López-López M.T., Aguilera F.S., Osorio R. Ion-modified nanoparticles induce different apatite formation in cervical dentine (2018) International Endodontic Journal 51 (9), pp. 1019-1029. https://doi.org/10.1111/iej.12918

*46. Osorio R., Toledano-Osorio M., Osorio E., Aguilera FS., Padilla-Mondéjar S., Toledano M. Zinc and silica are active components to efficiently treat in vitro simulated eroded dentin (2018) Clinical Oral Investigations 22 (8), pp. 2859-2870. https://doi.org/10.1007/s00784-018-2372-7

*47. Scionti G., Rodriguez-Arco, L., Lopez-Lopez, M.T., Medina-Castillo, A.L., Garzón, I., Alaminos, M., Toledano, M., Osorio, R. Effect of functionalized PHEMA micro- and nano-particles on the viscoelastic properties of fibrin-agarose biomaterials (2018) Journal of Biomedical Materials Research- Part A 106 (3), pp. 738-745. https://doi.org/10.1002/jbm.a.36275

*48. Toledano M., Osorio R., Guerado E., Caso E., Osorio E. Nanostructure in the trabecular bone of postmenopausal women: Mechanical and chemical analysis (2017) Injury 48 Suppl 6, pp. S26-S33. https://doi.org/10.1016/S0020-1383(17)30791-X

*49. Caso E., Sabiers C.C., López-Guillén D., Caso J., Toledano M., Osorio R., Osorio E., Lozano C., Guerado E. Inter-individual gene variants associated with trabecular bone plasticity: A step forward in the personal genomics of degenerative bone disease. (2017) Injury 48 Suppl 6, pp. S12-S25. https://doi.org/10.1016/S0020-1383(17)30790-8.

*50. Toledano M., Pérez-Álvarez MC, Aguilera F.S., Osorio E., Cabello I., Toledano-Osorio M., Osorio R. A zinc oxide-modified hydroxyapatite-based cement facilitated new crystalline-stoichiometric and amorphous apatite precipitation on dentine (2017) International Endodontic Journal, 50, Suppl 2, pp. e109-e119. https://doi.org/10.1111/iej.12807

*51. Toledano M., Osorio R., Osorio E., Cabello I., Toledano-Osorio M., Aguilera F.S. A zinc chloride-doped adhesive facilitates sealing at the dentin interface: A confocal laser microscopy study (2017) Journal of the Mechanical Behavior of Biomedical Materials, 74, pp. 35-42. https://doi.org/10.1016/j.jmbbm.2017.04.030

*52. Toledano M., Osorio R., López-López M.T., Aguilera F.S., García-Godoy F., Toledano-Osorio M., Osorio E. Mechanical loading influences the viscoelastic performance of the resin-carious dentin complex (2017) Biointerphases, 12 (2), 021001. https://doi.org/10.1116/1.4979633

*53. Toledano M., Osorio R., Osorio E., Medina-Castillo A.L., Toledano-Osorio M., Aguilera F.S. Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface (2017) Journal of the Mechanical Behavior of Biomedical Materials, 68, pp. 62-79. https://doi.org/10.1016/j.jmbbm.2017.01.026

*54. Toledano M., Osorio E., Aguilera F.S., Cabello I., Toledano-Osorio M., Osorio R. Ex vivo detection and characterization of remineralized carious dentin, by nanoindentation and single point Raman spectroscopy, after amalgam restoration (2017) Journal of Raman Spectroscopy, 48 (3), pp. 384-392. https://doi.org/10.1002/jrs.5055

*55. Osorio R., Alfonso-Rodríguez C.A., Osorio E., Medina-Castillo A.L., Alaminos M., Toledano-Osorio M., Toledano, M. Novel potential scaffold for periodontal tissue engineering (2017) Clinical Oral Investigations, 21 (9), pp. 2695-2707. https://doi.org/10.1007/s00784-017-2072

*56. Toledano M., Osorio R., Cabello I., Osorio E., Toledano-Osorio M., Aguilera F.S. Oral function improves interfacial integrity and sealing ability between conventional glass ionomer cements and dentin (2017) Microscopy and Microanalysis, 23 (1), pp. 131-144. https://doi.org/10.1017/S1431927617000010